Inherited Epigenetics Produced Record Fast Evolution
Posted in the Evolution Debate Forum
ScienceDaily (Feb. 29, 2012)— The domestication of chickens has given rise to rapid and extensive changes in genome function. A research team at Linköping University in Sweden has established that the changes are heritable, although they do not affect the DNA structure.
Humans kept Red Junglefowl as livestock about 8000 years ago. Evolutionarily speaking, the sudden emergence of an enormous variety of domestic fowl of different colours, shapes and sizes has occurred in record time. The traditional Darwinian explanation is that over thousands of years, people have bred properties that have arisen through random, spontaneous mutations in the chickens' genes.
Linköping zoologists, with Daniel Nätt and Per Jensen at the forefront, demonstrate in their study that so-called epigenetic factors play a greater role than previously thought. The study was published in the journal BMC Genomics.
They studied how individual patterns of gene activity in the brain were different for modern laying chickens than the original form of the species, the red jungle fowl. Furthermore they discovered hundreds of genes in which the activity was markedly different.
Degrees of a kind of epigenetic modification, DNA methylation, were measured in several thousand genes. This is a chemical alteration of the DNA molecule that can affect gene expression, but unlike a mutation it does not appear in the DNA structure. The results show clear differences in hundreds of genes.
Researchers also examined whether the epigenetic differences were hereditary. The answer was yes; the chickens inherited both methylation and gene activity from their parentages. After eight generations of cross breeding the two types of chickens, the differences were still evident.
The results suggest that domestication has led to epigenetic changes. For more than 70 % of the genes, domesticated chickens retained a higher degree of methylation. Since methylation is a much faster process than random mutations, and may occur as a result of stress and other experiences, this may explain how variation within a species can increase so dramatically in just a short time.
Nätt and Jensen's research may lead to a review of the important foundations for the theory of evolution.
“Transitional Molecular Fossils”
Since: Dec 06
Somewhere in Penn's Woods
....and more and more evidence of siRNA (small interfering RNA), specifically STTM in epigenetic based evolution:
Now, Guiliang Tang, an associate professor of biological sciences, has developed a way to put a single small RNA out of commission and observe what happens when it can't do its job.
To do this, Tang and his team threw a wrench into a well-understood process that controls leaf symmetry and the tendency of plants to grow upright.
First they synthesized a sequence of DNA that would make a custom-designed type of small RNA, called a small tandem target mimic, or STTM. Then they introduced their synthetic DNA in Arabidopsis, a plant often used in genetics research. Once in the Arabidopsis, the synthetic DNA began manufacturing many copies of the STTM.
Then all the little STTMs began locking onto strands of a specific type of RNA, right where the plant's small RNA would normally have cut them in two. That blocked its action, so the long RNA strands remained intact.
Furthermore, the procedure prompted the cell to destroy all of its own small RNAs that would normally have cut the RNA. Together, those two mechanisms allowed the long RNA to make its protein unabated.
The results were dramatic. The control Arabidopsis plants grew upward on a central stem with regularly shaped leaves and stems. The mutant plants were smaller, tangled, and amorphous.
Their method isn't limited to one small RNA involved in leaf symmetry in Arabidopsis.
"You can use this to study the function of any small RNA in the cell," says Tang.
Since: Nov 09
Cool stuff, this.
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