Judged:
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The clinically high correlation between smoking
and carcinoma of the lungs has been the focal
point in societal campaigns against the habit
and the tobacco lobby. In an overview of personal
history in a number of lung cancer patients
locally, we are struck by the more than
casual relationship between the appearance of
lung cancer and an abrupt and recent cessation
of the smoking habit in many, if not most
cases.
The association is more than just casual-development
of cancer within a few months of eschewing
cigarette smoking.
Over a period of 4 years, a total of 312 cases
were treated for carcinoma of pulmonary origin:
of this number, 182 patients had quit smoking
within 5 15 months prior to their being diagnosed
with lung cancer. Of the 182 patients 142 were
male and 40 were females, with ages ranged between
47 and 74.
Each one of had been addicted to the habit for
no less than 25 years, smoking in excess of 20 sticks
a day. The striking direct statistical correlation between
cessation of smoking to the development of
lung malignancies, more than 60% plus, is too glaring
to be dismissed as coincidental.
It is our premise that a surge and spurt in
re-activation of bodily healing and repair mechanisms
of chronic smoke-damaged respiratory epithelia
is induced and spurred by an abrupt
discontinuation of habit, goes awry, triggering
uncontrolled cell division and tumor genesis. In
normal tissue healing, anabolic and catabolic
processes achieve equilibrium approximately 6
8 weeks after the original insult. When an imbalance
occurs between these phases occur in the
healing process, disruptions in repair limitations
occur leading to tumor genesis this sequence is
best exemplified in the formation of keloids from
scars [1].
Nicotine stimulates corticotrophin-releasing
factor (CRF) besides increasing the level of adrenocorticotropic
hormone (ACTH), both of which
interfere with immune systems [2]. Abrupt withdrawal
of the addictive drug could trigger derangement
of the ‘smoking-steroid’ conferred immunity,
priming the healing lung epithelia to dangerous
levels uncontrolled cell division
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