Generic Depakote

Depakote (Generic name: Divalproex sodium) is a prescription medication used to treat the following conditions:

Mania - Depakote is approved to treat manic episodes associated with bipolar disorder (manic depression)

Epilepsy - Depakote is approved to treat complex partial seizures and simple or complex absence seizures

Migraines - Depakote is approved to help prevent migraine headaches (though it does not help treat a headache once it starts).

Several studies have evaluated the safety and effectiveness of this medication.

Mania
In one study, Depakote was compared to lithium (Lithobid, Eskalith) or a "sugar pill" (placebo) to treat people who were hospitalized with an episode of mania. After three weeks, those taking Depakote had at least as much improvement in bipolar symptoms as those taking lithium (and more improvement compared to those taking a "sugar pill").

Migraines
Another study looked at using the drug for migraine prevention. Those not taking Depakote experienced an average of almost six migraines in four weeks, while people taking it had only three to four migraines, on average.

Epilepsy
In one study, the drug was added on to other seizure medications in people with complex partial seizures that were not adequately controlled. Those who added Depakote to their seizure medications decreased their seizure frequency, compared to those who did not take the drug.

Other studies have shown that using it alone is also effective for complex partial seizures.

Some general considerations for when and how to take the medication include:

The drug comes in the form of delayed-release tablets and "sprinkle capsules."

It can be taken with or without food. If the medicine upsets your stomach, try taking it with food.

Do not crush, break, or chew the tablets, as this will destroy the protective coating.

Depakote Sprinkle capsules can be swallowed whole or can be opened and the contents sprinkled on a spoonful of soft food (such as pudding or applesauce). Do not chew the contents, as each tiny bead is delayed-release, with a special protective coating.

The medication should be taken at the same times each day to maintain even levels of the drug in your blood.

For the medication to work properly, it must be taken as prescribed. It will not work if you stop taking it.

Do not stop taking the medication without first discussing it with your healthcare provider

The medicine should be stored at room temperature, away from moisture and heat. You should store the tablets and capsules in an airtight container.

Keep Depakote and all other medications out of the reach of children.

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