tanezumab arthritis study

I have been part of the trials for this drug since February of this year. I have had three injections and my conditions with osteoarthritis have worsened at a faster rate than before I was in the study. The drug had no impact on my level of pain and since there is no placebo in the trial, I was receiving some amount of the drug.

Over the past month I have experienced some of the worst pain I have ever had with my ongoing battle with osteoarthritis. I had a hip replaced in 1997 and the pain in my hip prior to the replacement was unbearable, but recently, several joints have hurt as bad as my hip prior to replacement.

I hope Pfizer takes care of my concerns and provides some treatment if I have had a negative result from the trials.

My husband was in the trial since last fall and in Jan developed pain in his hip. By April it had worsened to the point of extreme loss of mobility. By early June, after some discussion with doctors etc., he was told he would need a hip replacement. We are still waiting from Pfizer for a determination.... Continually wanting additional information and making comments that he already had arthritis. Things are not going well. The study physician has been extremely helpful but can only do what Pfizer tells him..
Good luck getting Pfizer to do anything but give you more meds and stronger ones at that.

Wow! This is just what I have found. Pfizer is now trying to suggest that I already had arthritis and that ist is not their fault that my condition has worsened. I have fought arthritis since I was in my late thirties, I am now sixty. Since I was stupid enough to get into the study for Pfizer, I have had such a deterioration physically that I can't even measure it. The study doctor was all for getting to the bottom of this until last week when suddenly, probably because of Pfizer, he shifted gears and is suggesting that I am now on my own, that Pfizer has no responsibility.

Well, we will see about that. I was not interested in getting in a legal battle, but if Pfizer wants to fight with me, then let's get busy! I am the wrong one for them to disregard.

Thanks for sharing your comments, I hope more people find this and are encouraged enough to fight Pfizer.

As my father used to say "The bigger they are, the harder they fall".

I was also in the tanezumab clinical trial for study of hip pain due to arthritis and took tanezumab...I developed a serious shoulder injury (which others have experienced) and was told it is becasue of my box spring...I have a tempurpedic mattress. Anyway, I am attempting to deal with Pfzer directly which is kind of a joke. My shoulder may be damaged for life, I have loss the use of my right arm and they say it is becasue of a mattress I dont have. huuuuuummmmmmm.

That answers another of my issues. I also had a small injury to my right shoulder about the time I started the trial. That shoulder has worsened and additionally my left shoulder, for no apparent reason has progressively gotten worse over the past several months. I am sure this is all related and I intend to take action against the clinic and Pfizer. I am physically ruined by this trial, I am certain of it. Maybe there are not that many people affected, but I don't care about the statistics, I care about me, and you. Pfizer is a giant, a goliath. I am just a little guy, but I intend to make Pfizer accountable.

I have had to have surgery on my ankle. I was in the study for a year for my right knee. The knee is worst. I had to have plates, rods, pins, bone transplant, and bone marrow in my ankle. I will not know for 6 weeks if this will correct my problem or if I will have have an amputation.

As much as I didn't want to know why my right foot became so bad, and I hoped that it was just a temporary condition, your post has opened my eyes. Pfizer is finally going to approve a visit to a rheumotologist for me, but I feel like they will go to any and all extremes to avoid accepting responsibility. How did you deal with them and how did you get to the point you are now? Will you please keep me informed as your situation moves along, and I will keep you informed as well.

Jeff wrote:

As much as I didn't want to know why my right foot became so bad, and I hoped that it was just a temporary condition, your post has opened my eyes. Pfizer is finally going to approve a visit to a rheumotologist for me, but I feel like they will go to any and all extremes to avoid accepting responsibility. How did you deal with them and how did you get to the point you are now? Will you please keep me informed as your situation moves along, and I will keep you informed as well.

I broke my ankle in 1980. Had some surgery 2000 (ankle was deburred) The research company is checking all my records from the past. My insurance is paying.

Thanks for the info. I wish you all the best, and will at least continue to supply you with some moral support. I will keep you posted.

used tanezumab for 10 months in pfizer study ,had to have my hip replaced. would like to talk to others with same problem

I took Tanezumab from August 2009 to June 2010. When I reported that I suspected my arthritis was getting worse, it was IGNORED. I was NEVER informed by Pfizer that this drug could make the arthritis worse and I believe they lied both to patients and the FDA. I now have arthritis in many areas I did not before and requested treatment from Pfizer, once again IGNORED. Would like contact with other patients, particularly ones who have gotten help with this horrible issue.(email ekrenik @ hotmail . com) I do not have insurance and now live in far worse pain than before this "study". I am also appalled by the GARBAGE Pfizer has fed the media about patients becoming "too active". I ended up with a broken foot from just every day walking!

Elizabeth, you are probably one of many who became a victim of this study. I too have suffered multiple joints now with severe arthritis, joints that never bothered me prior to the study. I have been aggressive with the clinic and Pfizer, and at least I have authorization for some tests and consultation with a rheumatologist of my choosing. I don't know what my life is going to be like if this continues to get worse. I am miserable every day, all day, and all night. I will send you an email, please keep my address and I will keep yours, we may need each other in this fight.

Patients, this is VERY important: I have now been in touch with a patient in New York, and another in Seattle that have had identical experiences with this Pfizer drug trial that I had in Texas. We have been intentionally deceived and damaged for life as a result. The more people who share their stories with one another, the stronger the odds that Pfizer will be forced to take responsibility for our injuries. I am not looking to sue, only asking for care for the damage they caused, but getting nothing but lies in return as are others. If a lawsuit is unavoidable, there is truly strength in numbers. Please feel free to share your stories with me at ekrenik @ hotmail . com! I will keep it confidential and share with you any actions that can benefit us as a whole.

Elizabeth, Thanks for stressing the importance of sharing stories. It helps to know that others are still up for the fight against Pfizer. As you know from my emails, I am getting weary. I don't remember the last night that I was able to sleep for more than an hour or two. Maybe there is a way to get some help out of this dark place I find myself in, I hope so.

By the way, I am the Jeff that first posted from Puyallup Washington, I have since moved to Arizona.

STB wrote:

My husband was in the trial since last fall and in Jan developed pain in his hip. By April it had worsened to the point of extreme loss of mobility. By early June, after some discussion with doctors etc., he was told he would need a hip replacement. We are still waiting from Pfizer for a determination.... Continually wanting additional information and making comments that he already had arthritis. Things are not going well. The study physician has been extremely helpful but can only do what Pfizer tells him..
Good luck getting Pfizer to do anything but give you more meds and stronger ones at that.

Would like to hear more of your story so we can, as a whole, put pressure on Pfizer to live up to their contract to pay for the injuries they caused. e k r e n i k @ h o t m a i l . c o m

gloria wrote:

used tanezumab for 10 months in pfizer study ,had to have my hip replaced. would like to talk to others with same problem

Would like to hear more of your story so we can, as a whole, put pressure on Pfizer to live up to their contract to pay for the injuries they caused. e k r e n i k @ h o t m a i l . c o m

I started the study in May 2009 for arthrits in my right Knee. I am now barely able to walk, both knees now have severe arthritis and need to be replaced. If I am lucky I get 3-4 hrs of sleep a night.I am starting to have a lot of pain in my right hip and lower back, & my right sholder. It seems that each day more and more joint pains. There is so much more going on, but it would take to much time and several people above are have all the same issues.
Pfizer or the study Dr.(it has never been clear which) has paid for knee xrays and bone density test and they say they will pay for my knee replacement. This is great, but.... I have a lot of questions. What if this drug is not out of my system, what damage has been done, what if more joints go bad. Should I seek legal advise before I get my knees done? I am not out for money, I just want to protect my self if thing keep getting worse. How do I find info. about my options? If anyone can help please reply.

I am not surprised that people are starting to come forward. The round of trials I was in began the first of last year and now people are finding this forum because they question what they have been told by the clinics and Pfizer. It is my belief that many many many have been affected by Tanezumab in a negative way. Everyone needs to start retrieving records, communicate only in writing and by all means---Do Not sign any form of Release of Liability, or "here is your new hip, now we are done treating you, please sign here". This is not Pfizers first rodeo. They are very skilled at litigation and we all must be wary of their kindness and compassion. I can't believe this is all happening to so many of us. Be strong, Elizabeth has kept my spirits up, bless her.

Here is link to an official FDA complaint regarding damages done by a drug.

https://www.accessdata.fda.gov/scripts/medwat...

Elizabeth, I went to the link you posted and it said not to report Investigational (study) drugs. Isn't Tanezumab a study drug?