Plavix, Nexium Combination Raises Heart Risks When Used in Stent Patients

Nov 14, 2008 Full story: Bloomberg 29

Heart stent patients taking Bristol- Myers Squibb Co. and Sanofi-Aventis SA 's anti-clotting drug Plavix increased their risk of heart attacks and strokes if they also took anti-ulcer medicines like AstraZeneca ...

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Suzan Meijer

Amsterdam, Netherlands

#1 Jun 4, 2009
I also got in big trouble using Plavix and Nexium. Luckily I survived. I only needed three new stents. When I got another medicin for my stomac my INR raised extremely (from 2 to 10)and I needed vitamine K to bring it back. I thougt that the change if medication was for financial reasons but since this week I know about the effect of Nexium on Plavix. This is for me enough prove that Nexium in combination with Plavix is something to avoid. I've read this article and I am shocked and very sad that now, six months later!!!, so many people are still in risk loosing their health and even life because nobody is warned yet.
Rusty

Turtle Creek, PA

#2 Jun 10, 2009
The more I research this, the more confused I get. Has anyone come up with an viable alternative? I need the Plavix, and I have acid reflux.
Suzan Meijer

Amsterdam, Netherlands

#3 Jun 10, 2009
Rusty wrote:
The more I research this, the more confused I get. Has anyone come up with an viable alternative? I need the Plavix, and I have acid reflux.
Just use another medicine like Zantac.
Barbara Oklahoma

Paoli, OK

#5 Sep 25, 2009
i was prescribed plavix when I had my first sign of heart problems and then they put me on nexium because the medicine was messing with my stomach
I had 2 stent placements on the first hospital trip, then I believe it was approximately 9-12 months later one collasped. I had to have that one replaced. They had to leave the bad one in because they said it would cause more damage trying to retrieve it. In July of this year I went in to have the arterior gram like normal I began feeling the same symptoms as I did the very first time. When I came to from the anesthesia I was in for more than I was ever expecting. My Kidneys had litterally shutdown, my bowel section was totally unoperating, my right leg from the hip down to my knee is totally paralyzed, I have no feeling at all. My cardiologist diagnosed my condition as brought on by the mixing of Plavix and Nexium that caused my blood to cogulate that blocked all arteries 100%, it is a total miracls that I am still here to write about it today.
Barbara Oklahoma

Paoli, OK

#6 Sep 25, 2009
Rusty wrote:
The more I research this, the more confused I get. Has anyone come up with an viable alternative? I need the Plavix, and I have acid reflux.
My Cardiologist has placed me on pepcid rx Strength
Pat

Tulsa, OK

#7 Sep 29, 2009
I've been on Plavix almost a year and been taking Prilosac otc for acid reflux. Yesterday my cardiologist told me to start taking pepcid.

Since: Sep 09

Clayton, OK

#8 Oct 6, 2009
I have been on Nexium for years. I had three stents 1-23-09 and put on Plavix. 2-5-09 I had a heart attack and again 2-12-09. My cardiologist never mentioned the fact that Nexium and Plavix do not mix. My pharmacist advised me TODAY, 10-6-09 that the two medications do not mix. I have researched on the internet and the problem was very well known when my cardiologist sent me home with Plavix and Nexium.
Suzan Meijer

Amsterdam, Netherlands

#9 Oct 7, 2009
In The Netherlands the pharmacy's warn per july 2009 for this combination. It is not only the Nexium, there are more kinds.
It is very, very sad that so many people lost unneccesary their health or even lifes.
Bobby Caraway

United States

#10 Dec 16, 2009
I have been taking Nexium for almost fifteen years. When I developed acid reflux my physician tried me on everything he knew. I had truly reached a point where I said, "I can't keep on living like this!" Then, by chance, another physician tried me on Prilosec. It was a miracle drug for me and I now take Nexium which I can tell is an even better drug for acid reflex. About four years ago I had my first two stents placed. I now have ten to fifteen stents having lost count a long time ago. My Cardiologist has never warned me about this conflict nor have any other specialists. I learned about it on a sports radio show! It concerns me that I may have to stop the Nexium. My cadiologist says I must never, ever miss a day of my Plavix.
Suzan Meijer

Amsterdam, Netherlands

#11 Dec 17, 2009
I have since the end of may '09 Ranitidine for my stomach and I have no problems. It's not only Nexium but all medicins which have esomeprazol or any other protonpompremmers/-inhibitors (I don't know the English word for it.
A month ago my hart was checked and there was no more clotting than it was after the last stents given the end of may. This can mean that I am stable again like I was before I got the combination Nexium x Plavix.
I am sad and very, very angry that I have lost so much health by the angina pectoris I got from this medicincombination.
Mark Clark

Caddo, OK

#13 Feb 13, 2010
I had a stent placed 1-13-10. I was on Nexium and the doctor placed me on Plavix and about 2 weeks after the operation my head started feeling funny and I checked my pulse, my heart would beat 3 times then there was a pause then it would beat 3 more times then another pause. I went to the emergency room and my pulse was between 120 and 160 back and forth. They finally got my pulse down to 70 and kept me in the hospital for 3 days. They took me off of the nexium and put me on Pepcid. I asked them what caused my heart to beat like that and they said it was probably the nexium. They also said that Plavix and Nexium shouldn't be combined. I also have a pacemaker, while I was in the hospital my heartbeat would stay around 60. Now a week later my stomach has got some pains. I was wondering if this has happened to anyone else.
Suzan Meijer

Amsterdam, Netherlands

#14 Feb 14, 2010
Using medicins without something to protect your stomac can't be done. The Nexium for me was replaced with Ranitidine (Zantac) en I have all kinds of problems but not with my stomac.
I hope you cab get something for the stomacpain.
riblake

Cold Spring Harbor, NY

#16 Feb 20, 2010
Mark Clark wrote:
I had a stent placed 1-13-10. I was on Nexium and the doctor placed me on Plavix and about 2 weeks after the operation my head started feeling funny and I checked my pulse, my heart would beat 3 times then there was a pause then it would beat 3 more times then another pause. I went to the emergency room and my pulse was between 120 and 160 back and forth. They finally got my pulse down to 70 and kept me in the hospital for 3 days. They took me off of the nexium and put me on Pepcid. I asked them what caused my heart to beat like that and they said it was probably the nexium. They also said that Plavix and Nexium shouldn't be combined. I also have a pacemaker, while I was in the hospital my heartbeat would stay around 60. Now a week later my stomach has got some pains. I was wondering if this has happened to anyone else.
Almost same happened to me. I had 2 stents placed in june 2007 and was placed on Plavix. On July 24th 2009 my GI Physician advised me to take another nexium in addition to 1 nexium tablet I was already taking. On July 26 at 4AM I was awaken with rapid breathing which when transported to the Emergency was diagnosed as Ventricular Tachycardia. I came very close to expiring. By luck my brother-in- law a physician did all the right things to keep me alive.Two days later in the hospital awaiting placement of a defibrillator I asked my cardiologist why I wasn't receiving Nexium. He told me that Nexium interferes with Plavix and may infact caused my problem. In Dec of 2009 a friend of mine who knew I was on Plavix, called and asked me if I was on nexium, informing me that his GI physician had just notified him to get off Nexium. I still haven't heard from my GI physician. In fact I have an appointment with him this coming week. I wonder if this info has become known to all physicians. Ive asked around and find that the answer is no. Apparently whomever makes Nexium has not issued a warning
Mark Clark

Crescent, OK

#17 Feb 21, 2010
riblake wrote:
<quoted text>
Almost same happened to me. I had 2 stents placed in june 2007 and was placed on Plavix. On July 24th 2009 my GI Physician advised me to take another nexium in addition to 1 nexium tablet I was already taking. On July 26 at 4AM I was awaken with rapid breathing which when transported to the Emergency was diagnosed as Ventricular Tachycardia. I came very close to expiring. By luck my brother-in- law a physician did all the right things to keep me alive.Two days later in the hospital awaiting placement of a defibrillator I asked my cardiologist why I wasn't receiving Nexium. He told me that Nexium interferes with Plavix and may infact caused my problem. In Dec of 2009 a friend of mine who knew I was on Plavix, called and asked me if I was on nexium, informing me that his GI physician had just notified him to get off Nexium. I still haven't heard from my GI physician. In fact I have an appointment with him this coming week. I wonder if this info has become known to all physicians. Ive asked around and find that the answer is no. Apparently whomever makes Nexium has not issued a warning
I wonder if this is something a lawyer should check on??
kim hersey

Manistee, MI

#18 Mar 11, 2010
I had a heart attack in april of 2003, two stents and I am on both plavix and prilosec, I have been on nexium and protonix also, I have never had a problem again, but I will check with my doc.
Gin

Da Lat, Vietnam

#19 Mar 20, 2010
Thanks for all useful sharing information. Hope every patient can find what they need here.
This video is an explanation on the risks when combining Nexium to Plavix:


Nexium and other proton pump inhibitors, like Wyeth's Protonix, are used to treat chronic heartburn, in which stomach acids come back up the esophagus, causing pain and inflammation. Doctors frequently prescribe these drugs to patients on Plavix because the blood thinner has been linked to a higher risk of ulcers.

About trusted place to purchase Nexium and Plavix Generic drugs, you can visit www.gomedstore.com to be offered cheaper price.
lynneeeepooh

Barnegat, NJ

#20 Apr 16, 2010
I had a heart attack and bypass surgery in 2002. I've been on Plavix for many years. In 2008 I began having problems. I was started on Omeperazole. That year I had 2 heart attacks and 3 stents. In 12/08, I had a 3rd heart attack less than a week after the 3rd stent because it had occluded. I almost died and eventually wound up losing my left leg due to clotting. Does anyone know WHEN the drug company and FDA were aware of the drug interactions?
Oleksiy

Zhitomir, Ukraine

#22 Apr 23, 2010
http://tobuypills.com/ - buy your pills with the best prices!
Suzan Meijer

Amsterdam, Netherlands

#26 Jul 2, 2011
I am now two years without the combination Nexium/esomeprazol x Plavix/clopidogrel and without new problems. With this combination I got serious problems within six weeks and needed several stents. After this I started to use three kinds of blood thinners: Plavix, Ascal and a Coumarine.
The Ranitidine my stomach had to be replaced by another one. The first didn’t work for me, than I tried… Nexium/esomeprazole. I was worried to use this again but as I didn't use the Plavix anymore I am happy to say that now, after some months, I got no new problems.
I was still using two other blood thinners but since ten days I am trying to lower the dose of the Ascal. Now I use haves and I hope to reach a situation without new problems with using only Marcoumar (fenprocoumon)
Summary:
12-9-2008 Heart attack, too late in the hospital, quite big part of heart out of function;
3-10-2009 Restoration of blood circulation, reactivating of 'sleeping part of heart', start using Plavix. Didn't need the wheelchair anymore;
5-27-2009 and 6-02-2009 New stents and ended the use of Nexium;
6-2-2010 quit use of Plavix;
6-2-2009 until now, 7-2-2011 no new clots!

In Dutch:
http://www.ema.europa.eu/docs/nl_NL/document_...

In English:
http://www.ema.europa.eu/ema/index.jsp...

"The new concern relates to several recently published studies examining clinical outcomes of clopidogrel users. Taken together, these studies suggest that a significant interaction might occur between clopidogrel and members of the PPI class of medicines, making clopidogrel less effective when given with these medicines."
kathy

Conneaut, OH

#27 Jul 11, 2011
My husband has been on Plavix for one year following two stents and one balloon angioplasty. He has had increasing stomach problems. Underwent Endoscopy today. What a dilemma...if you take Plavix, you run the risk of a gastric bleed; if you add Nexium or any other proton pump inhibitors, you render the Plavix less effective. What are we to do?

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