Norvir, Ritonavir News

The US Food and Drug Administration reported Wednesday that the drug interactions between the hepatitis C virus protease inhibitor Victrelis and certain ritonavir-boosted human immunodeficiency virus protease inhibitors can potentially reduce the effectiveness of these medicines when they are used together.

The FDA warned on Thursday that drug interactions between the hepatitis C virus protease inhibitor boceprevir and some ritonavir-boosted HIV antivirals might lower the effectiveness of each when they are coadministered.

Merck & Co's recently approved Victrelis treatment for hepatitis C considerably lessens the effectiveness of some widely used medicines against the virus that causes AIDS, Merck and U.S. regulators said in separate reports.

If the double-click feature doesn't work in your browser, you can enter the word below: The hepatitis C protease inhibitor Victrelis has some significant drug-drug interactions with common Norvir -boosted protease inhibitor combinations, according to preliminary data from a clinical trial and a warning issued to health care providers by Merck on ... (more)

HIVandHepatitis.com A U.S. appeals court rules Prop. 8 gay/ same-sex marriage ban unconstitutional: http://t.co/QCITRukl Overall, use of antiretroviral therapy appears to be associated with a decreased likelihood of bone fractures among people with HIV, but whether specific drugs such as tenofovir increase the risk, reduce the risk, or have a ... (more)

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Aims:a f To evaluate potential drug interactions with antiretroviral therapies or supportive therapies for use in conjunction with the once-daily, next-generation non-nucleoside reverse transcriptase inhibitor GSK2248761 in patients with HIV-1 infection.

Raltegravir could have a "useful" role in HIV post-exposure prophylaxis, according to investigators from the US writing in the online edition of the Journal of Acquired Immune Deficiency Syndromes .