Kineret, Anakinra News

Molecular studies suggest that NALP3 is involved in the processing of interleukin-1beta , prompting us to investigate whether IL-1 blockade may be therapeutic in patients with MWS.

Many patients have mutations in the cold-induced autoinflammatory syndrome 1 gene, encoding cryopyrin, a protein that regulates inflammation.

Abstract Rheumatoid arthritis is a chronic inflammatory disease characterized by uncontrolled proliferation of synovial tissue and a wide array of multisystem comorbidities.

Molecular studies suggest that NALP3 is involved in the processing of interleukin-1beta , prompting us to investigate whether IL-1 blockade may be therapeutic in patients with MWS.

XOMA Ltd. announced today at the American Diabetes Association's 68th Scientific Sessions that a study of XOMA 052, a potent anti-inflammatory drug candidate, preserved insulin production, reduced fasting ...

Health Canada has approved a new, self-injectable drug for the treatment of rheumatoid arthritis.

From the 2nd Department of Cardiology and 1st Department of Orthopaedics , Athens University, Attikon Hospital, and Department of Pharmaceutical Chemistry, School of Pharmacy, University of Athens , Athens, ...

For a long time, few drugs were developed for rheumatological diseases. It was considered unattractive from a commercial viewpoint since relatively few patients suffered from them. via The Biotech Stock Blog

FDA on Tuesday approved certolizumab pegol, a pegylated tumor necrosis -alpha blocker, as a second-line treatment for moderate to severe Crohn's disease in adults. via ASHP

“Our analysis suggests that the use of etanercept or adalimumab in place of infliximab as a first-line biologic agent is likely to be considered cost effective”

For elderly and disabled rheumatoid arthritis sufferers, the Medicare Prescription Drug Improvement and Modernization Act brought the promise of better disease management with "biologic" drugs. via EurekAlert!

“This new indication for ORENCIA offers another treatment option to help improve signs and symptoms of this serious disease in pediatric and adolescent patients.”

ORENCIA may be used as monotherapy or concomitantly with methotrexate . ORENCIA should not be administered concomitantly with tumor necrosis factor antagonists and is not recommended for use concomitantly with ... via Rehab Management

Patients with systemic-onset juvenile idiopathic arthritis or adult-onset Still's disease who are resistant to conventional treatment, may benefit from therapy with the interleukin-1 receptor antagonist ... via Rehab Management

Halifax, Nova Scotia, Canada ? Dermatologists at the Dalhousie Medical School have discovered anakinra , a receptor-blocking medication, eases pain and suffering caused by Familial Cold Autoinflammatory ... via Dermatology Times

“It's like you're freezing from the inside out”

Barrie Ross and his colleagues have successfully ended a 20-year quest to find a treatment for Familial Cold Autoinflammatory Syndrome . via Science Daily

“A tip from a colleague turned us on to anakinra. It was an approved therapy for rheumatoid arthritis in Canada which meant that was safe to use.”

Relief is now available for 600 people around the world who suffer from a rare genetic condition triggered by exposure to cold. via Newswise

For more than 30 years, a Canadian woman and her siblings have endured a rare skin disease that at one time didn't even have a name, it is reported by the Daily Gleaner. via Fox News

By Karen Jowers - Staff writer Posted : Monday Mar 10, 2008 17:38:47 EDT The Defense Department is moving five more medications to its highest price tier, which means they will cost Tricare beneficiaries $22 ... via Army Times

The best treatment strategy for rheumatoid arthritis patients involves a drug combination -- choosing a lower-cost synthetic DMARD with one of the newer biologic drugs. via About.com

“Rheumatoid arthritis is a painful, degenerative disease that affects people of all ages and can profoundly impact quality of life”

For patients with rheumatoid arthritis, combining one well-known, lower-cost synthetic drug with one of six biologic medications often works best to reduce joint swelling or tenderness, according to a new ... via EurekAlert!

“Because mutant PSTPIP1 proteins interact with pyrin much more strongly than normal PSTPIP1, they cause uncontrolled or exaggerated activation of pyrin and consequently more secretion of IL-1 beta in these patients.”

Molecular biologists at Jefferson's Kimmel Cancer Center in Philadelphia have detailed the cascade of cellular events behind some potentially dangerous autoinflammatory diseases. via EurekAlert!