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New data suggest that breast cancer patients with HER2- and basal-molecular subtypes are more likely to respond to neoadjuvant chemotherapy than patients with luminal-type molecular subtype characteristics.

E-mail: kfoon@nvcancer.org Received 11 August 2009; Revised 16 October 2009; Accepted 4 November 2009; Published online 24 December 2009.

Researchers have developed a novel animal model showing that four commonly used chemotherapy drugs disrupt the birth of new brain cells, and that the condition could be partially reversed with the growth factor IGF-1. Published early online in the journal Cancer Investigation , the University of Rochester Medical Center study is relevant to the ...

Randomized, Controlled Trial of Cyclophosphamide, Methotrexate, and Fluorouracil Versus Cyclophosphamide, Doxorubicin, and Fluorouracil With and Without Tamoxifen for High-Risk, Node-Negative Breast Cancer: Treatment Results of Intergroup Protocol INT-0102 Export J Clin Oncol , Vol.

MethodsWe studied 438 tumors from 710 premenopausal women with node-positive breast cancer who received cyclophosphamide, epirubicin, and 5-fluorouracil or cyclophosphamide, methotrexate, and 5-fluorouracil as adjuvant chemotherapy in the randomized National Cancer Institute of Canada Clinical Trials Group Mammary 5 trial.

Roche announced today at the 51st Meeting of the American Society of Hematology in New Orleans, LA that the pivotal Phase III study CLL8 showed that patients with previously-untreated chronic lymphocytic leukemia survived their disease longer when treated with Rituxan compared to chemotherapy alone.

Mycophenolate mofetil is as efficacious as, but safer than, cyclophosphamide in the treatment of proliferative lupus nephritis: a meta-analysis and meta-regression Export Rheumatology In Rheumatology, Vol.

As Roche said at the 51st meeting of the American Society of Hematology , the trial showed that patients treated with the medicine and with chemotherapy lived longer than those treated with chemotherapy alone.

SOUTH SAN FRANCISCO, Calif. The Food and Drug Administration has turned down a request by two biotech companies seeking approval for a drug as a treatment for chronic lymphocytic leukemia.

A chemotherapy regimen including capecitabine is associated with a lower risk of breast cancer recurrence compared to a combination of standard drugs, according to research published online Nov.

Immunohistochemical studies revealed extensive gliosis and mononuclear phagocyte infiltration with corresponding upregulation of proinflammatory cytokines .

An article published Online First and in the December edition of The Lancet Oncology reports that addition of capecitabine to a standard chemotherapy regimen for breast cancer improves recurrence-free survival.

Abstract 10.1158/1078-0432.CCR-07-4310 Dynamic contrast-enhanced magnetic resonance imaging allows noninvasive, measurements of tissue microvessel perfusion and permeability.

Chemotherapy-induced alopecia is considered to be one of the most distressing adverse events resulting from chemotherapeutic treatment regimens, having serious psychosocial ramifications for the patient.

Correspondence: Jai Radhakrishnan, Columbia University Medical Center, 622 W. 168th St., PH4124, New York, New York 10032, USA.

We have all seen prescription drug commercials that end with a voice rapidly listing information about potential side effects and hazards.

More than 60% of patients with diffuse large B-cell lymphoma will be cured with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone .

Variability between individuals in the pharmacokinetics of cancer chemotherapy has important consequences in terms of therapeutic efficacy and safety.

Researchers have identified that Rituxan, a drug previously approved for the treatment of non-Hodgkin's B cell lymphoma and rheumatoid arthritis, can treat severe ANCA-associated vasculitis as effectively as cyclophosphamide, the current standard therapy.

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