Tuesday Aug 19
Inhibition of hERG Potassium Channels by Celecoxib and Its Mechanism
Celecoxib , a widely prescribed selective inhibitor of cyclooxygenase-2, can modulate ion channels independently of cyclooxygenase inhibition.
Tuesday Aug 19
Mechanisms of Kv2.1 channel inhibition by celecoxib - modification of gating and channel block
British Journal of Pharmacology , Vol. 159, No. 2. , pp. 405-418, doi:10.1111/j.1476-5381.2009.00539.x Background and purpose:a Selective cyclooxygenase-2 inhibitors such as rofecoxib and celecoxib were developed as NSAIDs with reduced gastric side effects.
UPDATE 1-Generic drugmaker Mylan trims forecast as FDA approval drags
Mylan Inc shaved the top end of its full-year revenue and earnings forecasts, citing delays in approval from the U.S. Food and Drug Administration for key generic drugs that it plans to launch this year.
Chilli pepper capsaicin may inhibit gut tumours & extend mice lifespan by 30%: Research
"Our data also suggested that TRPV1 triggering by dietary administration of capsaicin suppressed intestinal tumourigenesis," say researchers.
Celebrex shouldn't be your first choice for joint pain
A. In most cases, no-for several reasons. First, the drug, which in generic form is known as celecoxib, doesn't ease pain from osteoarthritis better than related drugs available without a prescription, including ibuprofen and naproxen , according to our Best Buy Drugs analysis.