I was diagnosed with RR MS in 1994. I was symptom free until 2000 at that time I was prescribed AVONEX. The initial side affects were overwhelming and I was depressed all the time. I was prescribed Lexapro for depression, and am still taking it. After 4 years, I tried COPaxone and that made me really ill with nausea, fever and vomiting. I stopped all treatment until 2007 and had a awful flare up with left me with numbness in both feet, bladder and bowel control problem, severe cold feet, chronic fatigue, difficulty walking and balance problems. I started Tysabri in April of 2008 and have not experienced any problems to date. I am working full time and leading a somewhat active life. I still feel tired and weak, but the diet change of no dairy, gluten, sugar and processed foods helps with the fatigue. I am constantly worried about PML with the Tysabri, and wish there was another treatment choice for me. I have read about LDN and wonder if there is anyone who is in the Pacific Northwest that has tried it, and can offer some advice. Also, has anyone tried Medical Marijuana for symptoms?